Work

Affordable, cleanroom-free millifluidic production of targeted lipid nanocarriers via additive manufacturing

Year: 2026

Type: article

Abstract: targeted delivery, showcasing the potential of our device to produce formulations for therapeutic delivery. As a flow-based method, VFF can facilitate rapid formulation investigation and produce large sample volumes for cell-based validation studies, whilst avoiding inter-batch sample variation. Furthermore, the accessible nature of this VFF approach will help to democratise millifluidics, facilitating the wider adoption of flow-based production methods to develop nanomedical formulations.

Source: Lab on a Chip

DOI: 10.1039/d3lc00995e

Authors: Callum D. Hay, Suchaya M. Mahutanattan, Colin P. Pilkington, Miguel Paez-Perez, Kimberly A. Kelly, Yuval Elani, Marina K. Kuimova, Nicholas J. Brooks, Michela Noseda, James W. Hindley, Oscar Ces

Institutions: Imperial College London, University of Virginia, King's College London

Language: English

Topic: Innovative Microfluidic and Catalytic Techniques Innovation

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: British Heart Foundation, Engineering and Physical Sciences Research Council, Biotechnology and Biological Sciences Research Council

Awards: Spatially resolved cellular and molecular drivers of cardiac remodelling in healthy and failing human hearts (joint funding with DZHK), 21ENGBIO: Microenvironment-Responsive Synthetic Cells for Cancer Drug Delivery, G6905147915, Dormant stem cells from adult myocardium (renewal), EPSRC Centre for Doctoral Training in Chemical Biology - Innovation for the Life Sciences

OpenAlex ID: W7118674697

FWCI: 5.367

Cites: 70

Cited by: 3

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