Topical propranolol for infantile hemangioma: a comprehensive review of mechanisms, clinical efficacy, and novel formulations
Year: 2026
Type: article
Abstract: Infantile hemangioma (IH) is the most common benign soft tissue tumor in children. While most exhibit a tendency for spontaneous regression, a minority can lead to severe, life-threatening complications, necessitating active intervention. Treatment modalities vary depending on the lesion's location, size, and depth. In recent years, topical β-blockers have increasingly become a preferred treatment option for many parents and clinicians. This review aims to systematically summarize the pharmacological mechanisms, clinical efficacy, safety profile, and formulation innovations of topical propranolol in the treatment of IH by synthesizing domestic and international literature, thereby providing a valuable reference for clinical practice and future research.
Source: Frontiers in Pediatrics
Authors: Feifan Chen, Li Yang, Kunpeng Li, Jiajun Chen, Wenying Liu, Yi Ji, Meng Xia, Jing Xie, Ke Ding, Qiang Zeng, Fang Hou
Institutions: North Sichuan Medical University, University of Electronic Science and Technology of China, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Southwest Medical University, Sichuan University, West China Second University Hospital of Sichuan University, West China Hospital of Sichuan University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
Awards: G1090224271, G625610187
OpenAlex ID: W7118687014