Work

Acquired Reactive Perforating Collagenosis Treated with Upadacitinib: A Case Report and Literature Review

Year: 2026

Type: article

Abstract: Acquired reactive perforating collagenosis (ARPC) is a rare perforating dermatosis linked to systemic diseases, with unclear pathogenesis and no standardized therapy. We report a 53-year-old male with ARPC who failed conventional treatments but improved rapidly with upadacitinib 15 mg/day for one month, followed by 15 mg every other day. After three months, most lesions resolved, leaving hyperpigmentation and scars. Literature review shows conflicting reports: one case of ARPC improved with upadacitinib, another developed ARPC during upadacitinib treatment for atopic dermatitis. Our findings suggest upadacitinib may be effective for ARPC, especially in pruritic patients, regardless of diabetes status.

Source: Clinical Cosmetic and Investigational Dermatology

DOI: 10.2147/ccid.s569903

Authors: Bo Xie, Xiaoyan Zhang, Xinxin Lei, Yuting Zhang, Qin Zhang, Yujian Ye

Institutions: Zhejiang Chinese Medical University, Third People's Hospital of Hangzhou

Language: English

Topic: Skin Diseases and Diabetes

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,836