Work

CPD-1 can compensate for EGL-21 to process neuropeptides

Year: 2025

Type: article

Abstract: mutants lacking carboxypeptidase E, a major neuropeptide processing enzyme. We also found that CPD-1 acts in intestinal cells and possibly GABAergic neurons to promote defecation. These results suggest that CPD-1 can process neuropeptides, specifically in the absence of EGL-21 .

Source: PubMed

DOI: 10.17912/micropub.biology.001965

Authors: David C Khawand, Amy K Clippinger, Michael Ailion

Language: English

Topic: Neuropeptides and Animal Physiology

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke

Awards: Proteins important for dense-core vesicle function, Exploring how cells generate and release distinct subpopulations of dense-core vesicles, Signaling Pathways that Modulate Neuronal Activity, Diabetes, Obesity and Metabolism Training Program