Year: 2026
Type: article
Abstract: Large language models have the potential to transform neurology by augmenting diagnostic reasoning, streamlining documentation, and improving workflow efficiency. This Mini Review surveys emerging applications of large language models in Alzheimer's disease, Parkinson's disease, multiple sclerosis, and epilepsy, with emphasis on ambient documentation, multimodal data integration, and clinical decision support. Key barriers to adoption include bias, privacy, reliability, and regulatory alignment. Looking ahead, neurology-focused language models may develop greater fluency in biomedical ontologies and FHIR standards, improving data interoperability and supporting more seamless collaboration between clinicians and AI systems. Two future developments have the potential to be particularly impactful: (1) the integration of multi-omic and neuroimaging data with digital-twin simulations to advance precision neurology, and (2) broader adoption of ambient documentation and other language-model-based efficiencies that could reduce administrative and cognitive burden. Ultimately, the clinical success of large language models will depend on continued progress in model robustness, ethical governance, and careful implementation.
Source: Frontiers in Digital Health
Authors: Donald C. Wunsch III, Daniel B. Hier
Language: English
Subfield: Health Informatics
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,077
OpenAlex ID: W7118763950