Work

Simultaneous detection of lymphocytes and tumor cells in vivo in response to STING-TLR9 immunotherapy with Raman active multiplexed gold nanostars

Year: 2026

Type: article

Abstract: Multiplexed gold nanostars enable in vivo and ex vivo SERS imaging of CD8 + T cells and VEGFR2 + tumor cells capturing dynamic T cell recruitment and vascular changes in the tumor to enable treatment response to immunotherapy.

Source: Nanoscale Horizons

DOI: 10.1039/d5nh00687b

Authors: Siddhant Kothadiya, Gabriel P. Cutshaw, Ansuja P. Mathew, Casey Zielinski, Rizia Bardhan

Institution: Iowa State University

Language: English

Topic: Gold and Silver Nanoparticles Synthesis and Applications

Subfield: Electronic, Optical and Magnetic Materials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Science Foundation, Iowa State University, National Institutes of Health, Division of Civil, Mechanical and Manufacturing Innovation

Awards: G125254765, Developing Multimodal Multiplexed ImmunoPET-Raman Probes to Guide Immunotherapies, Nanomanufacturing of Hybrid Nanocarriers and Understanding their Physicochemical Properties for Targeted Drug Delivery, G9000084502

OpenAlex ID: W7118768157

FWCI: 0.983

Cites: 46

Cited by: 1

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