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Unilateral Tongue and Lip Edema: A Rare Presentation of Angiotensin-Converting Enzyme (ACE) Inhibitor-Induced Angioedema

Year: 2026

Type: article

Abstract: Angiotensin-converting enzyme (ACE) inhibitor-induced angioedema is a rare but potentially life-threatening adverse effect that may occur years after treatment initiation. Although it typically presents with bilateral facial or oropharyngeal swelling, unilateral tongue involvement is exceptionally rare and diagnostically challenging. We report the case of a 77-year-old man on long-term ACE inhibitor therapy who presented with sudden unilateral tongue and lip edema. Symptoms improved with supportive treatment and drug discontinuation. This case highlights the importance of recognizing atypical presentations to ensure prompt diagnosis, appropriate management, and improved patient safety.

Source: Cureus

DOI: 10.7759/cureus.101033

Authors: Gonçalo Carneiro, Iara Ferreira, Catarina Reigota

Institutions: Unidade Local de Saúde de Entre Douro e Vouga, Unidade Local de Saúde de Coimbra

Language: English

Topic: Coagulation, Bradykinin, Polyphosphates, and Angioedema

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7118776965