Multiomics alterations associated with tolerance and response to simulated progressive hemorrhage in healthy adult humans
Year: 2026
Type: article
Abstract: This study investigated the first multiomics data for association with tolerance to central hypovolemia in humans. Analyzing gene expression, proteins, and genetic variants in individuals with high and low tolerance to simulated hemorrhage, the findings show that severe blood loss causes widespread transcriptional changes, including the activation of innate immune system pathways and inhibition of gas transport processes. This research can help identify molecular factors that influence individuals' tolerance levels for progressive blood loss.
Source: Physiological Genomics
Authors: Burook Misganaw, Seid Muhie, Aarti Gautam, Stacy-Ann Miller, Ida Nela Crespo Rosales, George I. Dimitrov, Bintu Sowe, Christopher P. Johnson, Shelly K. Roberts, Riley J. Regimbal, Chad C. Wiggins, Michael J. Joyner, Timothy B. Curry, Victor A. Convertino, Rasha Hammamieh
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Award: G4874655865
OpenAlex ID: W7118779480