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Cover Feature: From Structure to Function: Development of Relaxin‐3 Analogs and their Role in RXFP3 Signaling (ChemBioChem 1/2026)

Year: 2026

Type: article

Abstract: The RXFP3/Relaxin-3 system is implicated in behaviors such as addiction, anxiety and depression, making it an attractive pharmaceutical target. Because RXFP3 is primarily located in the central nervous system, achieving blood–brain barrier penetration is crucial. The cover depicts the relaxin family peptide receptor 3 and its ligand relaxin-3 in the bottom left corner, with key reported small molecules shown in white. The alpha helix in the background represents recently developed single-chain peptidomimetics. More details can be found in the Research Article by Mohammed Akhter Hossain and co-workers (DOI: 10.1002/cbic.202500664).

Source: ChemBioChem

DOI: 10.1002/cbic.70192

Authors: Isabelle Riches, Hongkang Wu, Predrag Kalaba, Ashish Sethi, Tim Lkhagvajargal, Philip J. Ryan, Ivan Maslov, Ross A. D. Bathgate, Mohammed Akhter Hossain

Institutions: The University of Melbourne, Florey Institute of Neuroscience and Mental Health, Australian Nuclear Science and Technology Organisation, Australian Synchrotron

Language: English

Topic: Pregnancy-related medical research

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W7118808654

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