Linking intestinal bitter taste receptors and GSPE-induced long-lasting benefits in ageing rats: an integrative analysis
Year: 2026
Type: article
Abstract: secretion, intestinal barrier dysfunction indices, some microbiota genera and several Tas2r transcripts among the 34 strongest discriminators. Tas2rs formed high-betweenness hubs linking epithelial integrity, inflammatory tone and butyrate-producing taxa. These findings indicate that intestinal type-2 bitter taste receptors (Tas2rs) may integrate multisystem regulatory networks fundamental to healthy ageing. Brief administration of grape-seed proanthocyanidin extract (GSPE) is sufficient to durably reprogramme Tas2r expression and the surrounding microbiota-endocrine-barrier landscape in aged rats.
Source: Food & Function
DOI: 10.1039/d5fo03241e
Institution: Universitat Rovira i Virgili
Language: English
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: hybrid
Awards: G1175115578, G132186627, G1622782223, G2038104832, G2064873908, G2262748287, G2355262757, G2462415295, G288263039, G3005324705, G300979063, G34346518, G3480869486, G3546882995, G410571670, G425668148, G451917667, G5080475149, G5117930183, G5539308778, G5852091828, G5967599077, G69051668, G76819071, G929308097
OpenAlex ID: W7118868639