Work

Clozapine‐Associated Pulmonary Embolism: Continuation of Clozapine Therapy With Concurrent Anticoagulation

Year: 2026

Type: article

Abstract: Clozapine, a gold standard for treatment-resistant schizophrenia, is associated with a range of adverse effects, including the rare but serious risk of pulmonary embolism (PE). The management of such complications, particularly in the absence of clear guidelines for preventive anticoagulation, poses significant challenges. We present a case of a male (in his late 30s) with schizophrenia who developed recurrent thromboembolic events during clozapine therapy. Despite the occurrence of a second PE, clozapine therapy was continued successfully with concurrent anticoagulation. This case highlights the need for individualized treatment strategies and underscores the critical gap in evidence regarding preventive anticoagulation in patients with clozapine.

Source: Case Reports in Psychiatry

DOI: 10.1155/crps/6686502

Authors: M. R. Jahangir, C. Heerema, J. Biedermann, S. Dieleman, N. H. Grootendorst-van Mil

Institution: Erasmus MC

Language: English

Topic: Venous Thromboembolism Diagnosis and Management

Subfield: Internal Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $790