Work

Recent advances in cassane diterpenoids: structural diversity and biological activities

Year: 2026

Type: article

Abstract: ). Cassane diterpenoids possess various pharmacological activities, including anti-inflammatory, antibacterial, cytotoxic, antiparasitic, antidiabetic, and neuroprotective effects. This work provides an update on the newly reported cassane diterpenoids from 2019 to 2025. In this work, cassane diterpenoids are categorized according to their carbon skeletons into usual tricyclic cassanes, tricyclic cassane with butanolide, cassane furanoditerpenoids, norcassanes, cassane ester amines, cassane amides, and penta-spiro cassanes. Their reported biological activities, together with biosynthetic pathways, isolation and purification, and structure-activity relationships, are discussed. A total of 238 compounds were discussed, and 55 references were listed. The reported findings expand the knowledge of chemical features and biological potential of cassane diterpenoids and support their further investigation as promising leads for drug discovery.

Source: RSC Advances

DOI: 10.1039/d5ra07088k

Authors: Sabrin R. M. Ibrahim, Hagar M. Mohamed, Samar S. A. Murshid, Asma Ahmad Nashawi, Gamal A. Mohamed

Institutions: Batterjee Medical College, Assiut University, Liwa University, Alexandria University, King Abdulaziz University

Language: English

Topic: Bioactive Natural Diterpenoids Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,042