The 2025 KDIGO guideline on the management of nephrotic syndrome in children: a comment of the European Renal Association Immunonephrology Working Group
Year: 2025
Type: article
Abstract: Despite advances and therapeutic progress, nephrotic syndrome (NS) in childhood remains challenging due to its heterogeneous presentation, variable response to treatment and the potential of adverse long-term kidney outcomes. The recently published KDIGO 2025 clinical practice guideline for the management of NS in children refines the definitions of relapse, infrequently- and frequently-relapsing NS and steroid-resistant NS. Herein we describe the revised definitions, summarize the key updates of the KDIGO 2025 guidelines and comment on the new treatment algorithm from a European viewpoint, highlighting the need for individualized approaches to minimize toxicity and optimize long-term kidney outcomes in NS in children.
Source: Clinical Kidney Journal
DOI: 10.1093/ckj/sfaf381
Institutions: University of Nicosia, National and Kapodistrian University of Athens, Limassol General Hospital, Linköping University, Innsbruck Medical University, Universität Innsbruck, Ludwig-Maximilians-Universität München, Karolinska University Hospital, Karolinska Institutet, Research Institute Hospital 12 de Octubre, Hospital Universitario 12 De Octubre, Istanbul University, University College Cork, Cork University Hospital, Hospital Clínic de Barcelona, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universitat de Barcelona, Queen Elizabeth University Hospital, Leiden University, Leiden University Medical Center, Universitätsklinikum Aachen, RWTH Aachen University, Bambino Gesù Children's Hospital, Istituti di Ricovero e Cura a Carattere Scientifico
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,335
OpenAlex ID: W7118912940