Interplay between medical and interventional therapies in valvular heart disease and heart failure: an expert opinion paper
Year: 2026
Type: article
Abstract: Heart failure (HF) and valvular heart disease (VHD) often coexist and share complex pathophysiological pathways. Traditional management strategies follow a step-by-step approach, prioritizing guideline-directed medical therapy (GDMT) and reserving interventional (surgical or percutaneous) options only in case of persistent symptoms or worsening HF after GDMT. However, greater experience with the use of percutaneous procedures, even in high-risk patients, could support a more integrated approach, which exploits the synergistic effects of medical and interventional therapies to increase the tolerability of one vs the other, thereby improving quality of life and outcomes through their synergic effects. This expert opinion paper summarizes current data and evolving practices in the management of VHD in patients with HF, including secondary mitral regurgitation, aortic stenosis, aortic regurgitation, and tricuspid regurgitation.
Source: ESC Heart Failure
Institutions: University of Brescia, Azienda Socio Sanitaria Territoriale di Cremona, Vita-Salute San Raffaele University, IRCCS Ospedale San Raffaele, Institutul de Urgenţă pentru Boli Cardiovasculare "Prof.Dr. C.C. Iliescu", American Heart Institute, Cairo University, Medical University of Vienna, Brigham and Women's Hospital, Harvard University, University of Balamand, IRCCS Istituto Auxologico Italiano, University of Milano-Bicocca, Johannes Gutenberg University Mainz, University Medical Center of the Johannes Gutenberg University Mainz, German Centre for Cardiovascular Research, Deutsches Herzzentrum der Charité, Charité - Universitätsmedizin Berlin, Ziekenhuis Oost-Limburg, Hasselt University
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,850
Funders: Bristol-Myers Squibb, AstraZeneca
OpenAlex ID: W7118960379