Work

A modular silk–collagen scaffold to model dorsoventral spinal cord organization using human pluripotent stem cells

Year: 2026

Type: article

Abstract: . While developed for spinal cord modeling, our fabrication approach is generalizable to other tissues and regions of the CNS, enabling spatial control of multiple tissue compartments. We anticipate that long-term culture with added supportive cell types will foster greater complexity and open avenues for future functional and translational applications.

Source: Journal of Materials Chemistry B

DOI: 10.1039/d5tb02074c

Authors: Marly Coe, Emily L. Pallack, Diya D. Patel, David L. Kaplan, Nisha R. Iyer

Institution: Tufts University

Language: English

Topic: 3D Printing in Biomedical Research

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

Funders: National Institute of Biomedical Imaging and Bioengineering, Congressionally Directed Medical Research Programs, Army Research Office, National Science Foundation Graduate Research Fellowship Program

Awards: G1095998094, Bioengineered 3D Human Brain Systems to Investigate Risk Factors, Mechanisms, and Treatments for Traumatic Brain Injury-Induced Alzheimer's Disease, G3475398701, G6422156701