Work

Uncommon clinical presentations and diagnostic difficulties of antiphospholipid syndrome associated with cryptococcal meningitis: A case study

Year: 2026

Type: article

Abstract: Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by thrombosis and obstetric morbidity. We report a 23-year-old female with APS who developed cryptococcal meningitis (CM) following immunosuppressive therapy. Diagnosed via cerebrospinal fluid (CSF) culture and MRI showing infarction, she had concomitant renal and hepatic failure, making amphotericin B contraindicated. Consequently, an individualized regimen comprising voriconazole and 5-fluorocytosine (5-FC) was initiated, resulting in significant clinical improvement. This case underscores that CM is a serious opportunistic infection in patients undergoing immunosuppression for APS, highlighting the need for vigilant monitoring and tailored antifungal strategies for multi-organ dysfunction.

Source: Medical Mycology Case Reports

DOI: 10.1016/j.mmcr.2026.100760

Authors: Zhengxiang Lv, Xiaodong Liu, Ping Xu

Institutions: Zunyi Medical University, Affiliated Hospital of Zunyi Medical College

Language: English

Topic: Fungal Infections and Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $650