Work

Thrombospondin 1 aggravates cardiac remodeling in heart failure with preserved ejection fraction by inhibiting mitophagy

Year: 2026

Type: article

Abstract: as a key suppressor of mitophagy in HFpEF and a potential therapeutic target for this prevalent condition.

Source: iScience

DOI: 10.1016/j.isci.2026.114639

Authors: Xingpeng Bu, Shuo Sha, Zhenzhen Zhang, Sicheng Bian, Shuhui Feng, Chunxia Li, Lei Wang, Huanzhen Chen

Institutions: Shanxi Medical University, Shanxi Academy of Medical Sciences, MetroHealth, Case Western Reserve University, First Hospital of Shanxi Medical University

Language: English

Topic: Cardiac Fibrosis and Remodeling

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: Health Commission of Shanxi Province, ShanXi Science and Technology Department

Awards: G4887900310, G7381414352, G953298376

OpenAlex ID: W7118998285

FWCI: 4.824

Cites: 48

Cited by: 1

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