Two New Prunasinoids From the Leaves of Elaeocarpus bachmaensis and Their Antidiabetic Activity
Year: 2026
Type: article
Abstract: ABSTRACT Two new prunasines, 6 ' ‐ O ‐ p‐trans ‐coumaroyl prunasin ( 1 ) and 6 ' ‐ O ‐ p‐cis ‐coumaroyl prunasin ( 2 ), together with six known compounds, afzelin ( 3 ), tamarixetin 3‐ O ‐rhamnoside ( 4 ), mearnsitrin ( 5 ), c is ‐linalool‐3,6‐oxide β ‐D‐glucopyranoside ( 6 ), n ‐hexyl‐ O‐β ‐D‐glucoside ( 7 ), and cucurbitacin F ( 8 ), were isolated from the leaves of Elaeocarpus bachmaensis collected in Bach Ma National Park, Vietnam. Their chemical structures were elucidated by one‐dimensional nuclear magnetic resonance (1D‐NMR), 2D‐NMR, and high‐resolution mass spectrometry spectra. Bioassays revealed that compound 6 inhibited α‐amylase significantly with a half‐maximal inhibitory concentration (IC 50 ) value of 137.3 ± 14.4 µM, whereas compounds 1 – 5 inhibited α‐glucosidase significantly with IC 50 values ranging from 82.4 ± 10.4 to 160.0 ± 19.9 µM. These findings suggest that E. bachmaensis may serve as a promising natural source for the development of antidiabetic agents. This is the first report on the chemical composition and bioactivity of the E. bachmaensis species.
Source: Chemistry & Biodiversity
Authors: Phan Thi Diem Tran, Vu Thi Thanh Tam, Tran Phuong Ha, Le Trung Hieu, Ton That Huu Dat, Le Canh Viet Cuong
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
Award: G2662717643
OpenAlex ID: W7119002334