Work

Visualising viral interactions and mechanisms at the nanoscale with expansion microscopy

Year: 2026

Type: article

Abstract: Expansion microscopy is a groundbreaking technique that enables nanoscale imaging of biological specimens using standard optical microscopes. By embedding specimens in swellable hydrogels, it achieves sub-diffraction resolution. Compatible with various tissue types, it offers 3D, multi-colour visualisation of cellular and sub-cellular structures. While challenges remain, like sample isotropy and preservation of molecular integrity, expansion microscopy is a transformative tool for cell and neurobiology. Here, we discuss its potential for virology.

Source: npj Viruses

DOI: 10.1038/s44298-025-00169-y

Authors: Lisa Övermöhle, Maximilian Baum, Rohan Bhatia, Karin Byskata, Katharina M. Scherer

Institution: University of Bonn

Language: English

Topic: Advanced Fluorescence Microscopy Techniques

Subfield: Biophysics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,790

Funders: Horizon 2020 Framework Programme, Erasmus+