Work

Enhancing the Oral Bioavailability of a Poorly Soluble Pan-CK2 Kinase Inhibitor: Leveraging a Phosphate Prodrug Strategy to Overcome Dissolution-Limited Absorption and Improve Systemic Exposure during Dose Escalation

Year: 2026

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c03141

Authors: Murugaiah A. M. Subbaiah, Naveen Manjunath, Thangeswaran Ramar, Mathiazhagan Annadurai, Naveen Kumar Dhondi, Tarun Sharma, Sheelendra Singh, Megha Thakur, Priyadeep Bhutani, Shahe Mahammad, Srinivas Kasibhatla, Sridhar Desikan, Kurt Zimmermann, Xiaopeng Sang, Gerry Everlof, Mary Obermeier, Aberra Fura, Ashok V. Purandare

Institutions: Bristol-Myers Squibb (India), Biocon (India), Bristol-Myers Squibb (United States)

Language: English

Topic: Drug Solubulity and Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

OpenAlex ID: W7119019601

FWCI: 11.93

Cites: 46

Cited by: 4

Related to: