Work

Microfluidics for cell therapy and manufacturing in oncology and regenerative medicine

Year: 2026

Type: article

Abstract: Microfluidics has offered invaluable insight into diagnostics and point-of-care applications due to its small footprint, low costs, and minimal power requirements. As cellular manufacturing has shown significant promise for treating previously insurmountable diseases, microfluidics has expanded its reach into immunotherapy and regenerative medicine with a clinical perspective. Conventional methods to reprogram a target cell to improve prognosis, while innovative on their own, face challenges that miniaturized systems are poised to address. Here, we provide an overview of microfluidic-based technology that highlights significant strides within the field of cell manufacturing to treat cancer and degenerative diseases. We highlight commonly used mechanisms to isolate, transfect, and expand target cells in microfluidic devices. We discuss specific innovative microfluidic-based approaches that demonstrate comparable or exceptional performance compared to traditional methods.

Source: Lab on a Chip

DOI: 10.1039/d5lc00492f

Authors: Josie L. Duncan, Julio P. Arroyo, Rafael V. Davalos

Institutions: Georgia Institute of Technology, Emory University, The Wallace H. Coulter Department of Biomedical Engineering

Language: English

Topic: Microfluidic and Bio-sensing Technologies

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Science Foundation, National Institutes of Health, National Center for Advancing Translational Sciences