Work

Omega-3 Fatty Acids: A Review on Molecular Mechanism as Regenerative Medicine

Year: 2026

Type: article

Abstract: Tissue regeneration is a complicated physiological process which is necessary to preserve skin's integrity after injury. Severe health problems can result from impaired wound healing, which is frequently linked to problems including diabetes and vascular disorders. ω-3 Polyunsaturated fatty acids (PUFAs), which include EPA and DHA, have become more recognized for their capacity to enhance wound healing and tissue regeneration. ω-3 fatty acids are used as regenerative medicine through various molecular mechanisms. Because of their anti-inflammatory and immunomodulatory characteristics, ω-3 PUFAs, especially EPA and DHA, have the potential to significantly improve tissue regeneration and wound healing. They enhance tissue quality, lessen scarring, and encourage the production of collagen. To improve dosage, administration techniques, and their effectiveness for various wound types, further research is necessary. This illustrates the potential benefits of using ω-3 PUFAs as an adjuvant for wound care. Current research on the processes by which ω-3 PUFAs affect different activities is summarized in this review. Key studies indicate that ω-3 PUFAs work through anti-inflammatory and immunomodulatory mechanisms, supporting more efficient and effective wound healing. They stimulate collagen synthesis, minimize scarring, and improve overall tissue quality. Despite promising evidence, additional investigation is required to ascertain the best dosage, the best ways to administer them, and the extent to which they are beneficial for different kinds of wounds. The analysis finds that ω-3 PUFAs have substantial promise for therapeutic use in wound management, providing a supplementary approach to existing treatments. Future studies should focus on improving treatment protocols.

Source: Advances in Pharmacology and Pharmacy

DOI: 10.13189/app.2026.140103