Work

Lactate dehydrogenase to albumin ratio as a convenient parameter for predicting the severity of Behçet disease: a cross-sectional study

Year: 2026

Type: article

Abstract: BACKGROUND: We investigated whether the ratio of lactate dehydrogenase (LDH) to albumin could be used as a diagnostic marker for Behçet's disease compared to the healthy population and as a marker to assess the severity and activity of the disease. METHODS: The research was conducted as a cross-sectional study. Patients aged 18-69 years presenting to the Behçet's disease Outpatient Clinic over a three-year period and healthy individuals with a similar age and gender distribution formed the two study groups. LDH and albumin levels, and the LDH/albumin ratio were compared between the groups. RESULTS: The study was conducted in 349 people, 160 patients with Behçet's disease and 189 healthy controls. The LDH/albumin ratio was significantly higher in the Behçet's group than in the control group. This ratio was significantly different according to the severity of the disease, the presence of genital ulcers, papulopustular lesions and joint involvement (p < 0.05). Duration of symptoms was positively correlated with LDH/albumin ratio values (r = 0.259, p = 0.001). ROC analysis of the LDH/albumin ratio in the severe versus not severe groups based on Behçet's disease severity showed an area under the curve (AUC) of 0.704 (95% CI: 0.586-0.821) and a cut-off value of 57.46, with a sensitivity of 57.7% and specificity of 72.4%. CONCLUSION: The LDH/albumin ratio is a promising parameter in patients diagnosed with Behçet's disease compared to healthy controls, with a cut-off value of 57.46 for distinguishing severe from non-severe disease. TRIAL REGISTRATION: This study was registered under ID number NCT06276829 (Study Record Dates:18.02.2024).

Source: BMC Immunology

DOI: 10.1186/s12865-025-00706-7

Authors: Erdal Pala, Mustafa Bayraktar

Institution: Atatürk University

Language: English

Topic: Ocular Diseases and Behçet’s Syndrome

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,090