Work

Unveiling the Uncommon: A Rare IgE-Mediated Presentation of Multiple Drug Hypersensitivity Syndrome

Year: 2026

Type: article

Abstract: Multiple drug hypersensitivity syndrome (MDHS) is characterized by hypersensitivity reactions to two or more unrelated drugs. Although it is commonly associated with delayed reactions, we report a rare case of immediate IgE-mediated MDHS in a 30-year-old female who reacted to levofloxacin and ibuprofen. Both reactions were confirmed through drug challenges, while acetylsalicylic acid was tolerated, excluding COX-1 cross-reactivity. This case highlights the importance of recognizing IgE-mediated MDHS and performing thorough allergy diagnostic workups to ensure accurate management and patient safety.

Source: Cureus

DOI: 10.7759/cureus.100855

Authors: Ana Vitória Soares, Diogo Mota, Daniela Brandão Abreu, Eunice Dias-Castro, Leonor Carneiro-Leão

Institutions: Universidade do Porto, Hospital de São João

Language: English

Topic: Drug-Induced Adverse Reactions

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7119089089