Work

Prediction of stroke recurrence for patients with middle cerebral artery atherosclerotic disease by CT perfusion

Year: 2026

Type: article

Abstract: Background This paper aimed to test the feasibility of computed tomography perfusion (CTP) in predicting stroke recurrence in patients with symptomatic middle cerebral artery atherosclerotic disease. Methods This is a retrospective study. 322 patients from 4 advanced stroke centers diagnosed as symptomatic middle cerebral artery atherosclerotic disease, including severe stenosis and occlusion were recruited. All patients underwent head CTP, digital subtraction angiography (DSA), MR 14-21 days after onset. Stroke recurrence of patients within 3 months was recorded. Patients were divided into recurrence group and control group according to whether stroke recurrence 3 months after onset. The association of imaging characteristics, other risk factors and patients stroke recurrence was assessed. Results 104 patients presented stroke recurrence within 3 months after onset. Patients in recurrence group showed more severe vascular stenosis ( p < 0.001) and presented with larger hypoperfusion area than control group, as shown by larger Tmax>4 s, Tmax>6 s, Tmax>8 s, Tmax>10s volume ( p < 0.001). The multiple logistic regression showed that the volume of Tmax>4 s (OR = 1.061 per 10 mL increase, 95% CI: 1.005–1.122, p = 0.033) and Tmax>6 s (OR = 1.265 per 10 mL increase, 95% CI: 1.093–1.483, p = 0.002) at 14–21 days after stroke were strongly associated with stroke recurrence, Tmax>4 s (AUC = 0.76, 95% CI: 0.70 to 0.81, p < 0.001) and Tmax>6 s (AUC = 0.74, 95% CI: 0.68 to 0.81, p < 0.001) volume had a high discriminative ability for a poor outcome. Tmax>4 s volume larger than 133.60 mL being an optimal cutoff (sensitivity = 80.7% and specificity = 58.6%, Youden index = 39.3%) and Tmax>6 s volume larger than 17.95 mL being an optimal cutoff (sensitivity = 83.5% and specificity = 58.7%, Youden index = 42.2%). Conclusion Symptomatic middle cerebral artery atherosclerotic stenosis or occlusion patients with severe hypoperfusion might suffer a higher risk of stroke recurrence. Volume of Tmax>4 s and Tmax>6 s in CTP could be used to predict the prognosis of these patients.

Source: Frontiers in Neurology

DOI: 10.3389/fneur.2025.1739005