The lactate-GPR81-PKA axis regulates exercise-induced central fatigue in male mice
Year: 2026
Type: article
Abstract: Exercise-induced fatigue is regulated by factors derived from the central nervous system (CNS), including neurotransmitters and metabolic signals. However, the underlying mechanisms remain largely obscure. Here, we demonstrate that lactate activates GPR81 in the motor cortex to inhibit PKA phosphorylation, thereby contributing to central fatigue during exercise. These findings reveal a vital role of lactate-GPR81-PKA axis in the motor cortex during exercise and provide a potential target for alleviating exercise-induced central fatigue.
Authors: Junxia Li, Miaomiao Tan, Zegang Hu, Shuhong Zhou, Zhengbi Liu, Chunxiang Wang, Ping Li, Fabo Shan
Institution: Army Medical University
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Award: G382250633
OpenAlex ID: W7119130125