Year: 2026
Type: article
Abstract: Three pairs of undescribed enantiomeric γ-pyrone derivatives placidenes G-I (1-3), together with two new congeners placidene J (4)/isoplacidene J (5) and two known compounds 6 and 7, were isolated from the marine mollusk Placida dendritica. Compounds 1a/1b-3a/3b were further separated by chiral-phase high-performance liquid chromatography. The structures were elucidated by comprehensive spectroscopic analysis, high-resolution electrospray ionization mass spectrometry, time-dependent density functional theory/electronic circular dichroism calculation, and X-ray diffraction analysis. In bioassays, compounds 1-5 exhibited moderate nitric oxide inhibition from 28.2% to 51.9% on RAW264.7 inflammatory cells at 20 µM without notable cytotoxicity.
Source: Chemistry & Biodiversity
Authors: Hao Wang, Wen‐Xuan Li, Chao Ru, Zhen Gao, Xu‐Wen Li
Language: English
Subfield: Biotechnology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7119142903