Work

Evaluation of Hemorrhage Risk and Predictors Following Stereotactic Radiosurgery for Cerebral Arteriovenous Malformations: A Retrospective Single-center Study

Year: 2026

Type: article

Abstract: Purpose: Radiation therapy is a well-established treatment method for cerebral arteriovenous malformations (AVMs) used in combination with other treatment modalities or alone. This study evaluated the postintervention bleeding risk of cerebral AVMs treated with stereotactic radiosurgery (SRS) using a linear accelerator (LINAC) and identified predictors of posttherapeutic hemorrhage. Methods and Materials: A retrospective analysis was conducted on 134 consecutive patients with AVMs treated with LINAC-based SRS between 1983 and 2022 at the department for Radiotherapy and Radiation Oncology at the Marburg University Hospital. Patients were followed for a median of 49 months. Statistical analysis was performed to assess the influence of variables such as AVM grade, prior treatment, SRS dose, and other clinical factors on post-SRS bleeding risk. Results: = .005), were associated with increased posttherapeutic hemorrhage risk. In contrast, factors such as age, sex, and SRS dose showed no significant influence. Two bleeding events occurred even after presumed angiographic obliteration. Conclusion: LINAC-based SRS for AVMs is associated with with a relatively low risk of posttreatment hemorrhage, with an annual bleeding rate lower than that of untreated AVMs and comparable with the risk found in previous studies. Higher AVM grades and prior treatments are key predictors of post-SRS hemorrhage. Given the possibility of hemorrhage even after angiographic obliteration, close long-term follow-up is recommended. Modern imaging techniques may enhance postobliteration monitoring in high-risk cases.

Source: Advances in Radiation Oncology

DOI: 10.1016/j.adro.2025.101982