Work

Efficacy of Elaeagnus multiflora and Cynanchum wilfordii Complex Extract on Male Lower Urinary Tract Symptoms: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Year: 2026

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: Purpose: Purpose: Lower urinary tract symptoms (LUTS) in men substantially impair quality of life and are commonly treated with alpha-blockers or 5-alpha reductase inhibitors, which may cause adverse effects.Elaeagnus multiflora and Cynanchum wilfordii, traditional herbal remedies, have shown potential benefits in testosterone regulation and benign prostatic hyperplasia (BPH); however, clinical evidence supporting their efficacy in LUTS remains limited.This study evaluated the efficacy and safety of the E. multiflora and C. wilfordii complex (NET1701) in men with LUTS.Materials and Methods: Materials and Methods: In this randomized, double-blind, placebo-controlled trial, 100 men aged 40-80 years with moderate LUTS (International Prostate Symptom Score [IPSS] 8-19) were randomized to receive NET1701 (325 mg/d) or placebo for 12 weeks.The primary outcome was the change in total IPSS from baseline to 12 weeks.Secondary outcomes included IPSS subscores, maximum urinary flow rate (Qmax), post-void residual volume (PVR), serum testosterone levels, and safety.Results: Results: At 12 weeks, the NET1701 group showed a significantly greater reduction in total IPSS compared with placebo (-5.67±3.86 vs. -1.00±4.30;p<0.0001).Significant improvements were observed in several IPSS subscores, including incomplete emptying, frequency, intermittency, and weak stream (p<0.05).Although Qmax and PVR did not differ significantly between groups, urinary symptom-related quality-of-life scores improved significantly in the NET1701 group (p<0.0001).NET1701 was well tolerated, with no severe adverse events reported.Conclusions: Conclusions: The E. multiflora and C. wilfordii complex (NET1701) significantly improved LUTS severity and quality of life without notable adverse effects.These findings suggest that NET1701 may represent a promising phytotherapeutic option for the management of male LUTS.Further long-term studies are needed to confirm its sustained efficacy and safety.

Source: The World Journal of Men s Health

DOI: 10.5534/wjmh.250239