Year: 2026
Type: preprint
Study design: Observational Study
Abstract: Ebola virus disease (EVD) survivors often present with clinical sequelae after acute disease resolution, called post-Ebola syndrome (PES). Why some survivors develop these sequelae and others do not is poorly defined. Altered metabolism has been noted in acute EVD but not studied in PES. We identified differential expression of metabolites involved in multiple metabolic pathways in EVD survivors with PES. This included the tricarboxylic acid cycle, amino acid, nucleotide, and short chain fatty acid metabolism. Several of these pathways are associated with immune dysfunction. The identified metabolites have potential use as biomarkers of post-Ebola syndrome.
Source: medRxiv
Institutions: Tulane University, Washington State University
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: West African Emerging Infectious Disease Research Center (WA-EIDRC), Clinical Sequelae and Urogenital Viral Dynamics in Survivors of Ebola Virus Disease, The Protective and Pathologic Features of the EVD Survivor Immune System, The Role of Viral Exposure and Age in Alzheimer's Disease Progression, Tulane StARR Program
OpenAlex ID: W7119187376