High-throughput bioprinted 3D cultures for probing host–pathogen interactions in bioinspired microenvironments
Year: 2026
Type: article
Abstract: in stiff microenvironments, with decreased cytokine secretion of IL-6 and IL-1β and elevated IL-10 and TNF-α compared to healthy compliant microenvironments, suggesting that microenvironment properties may shape initial immune responses. This high-throughput, accessible controlled platform provides opportunities for understanding human host-pathogen interactions and a foundation for identifying therapeutic strategies for bacterial infections in well-defined physiologically relevant microenvironments.
Source: RSC Applied Polymers
DOI: 10.1039/d5lp00285k
Institution: University of Delaware
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: diamond
Awards: G1177608224, G1451002057, G1703205069, G1854284042, G3115553707, G3162362856, G366302655, Discovery of Chemical Probes and Therapeutic Leads, Phase II, Unraveling fibrosis with dynamic microenvironments and molecular tools, G4201529120, G442499865, G4444685404, G4455334633, G5594047776, G5641144139, Delaware INBRE, G6345397415, Graduate Research Fellowship Program (GRFP), University of Delaware MRSEC - Center for Hybrid, Active, and Responsive Materials (CHARM), G7298979495, G8414554082, G9000014540, G9000019295, G9000042617, G9000073993, G9000093202, G9000254656
OpenAlex ID: W7119197754