Work

Manipulation of autophagy by sexually transmitted infections: new opportunities for intervention

Year: 2017

Type: article

Abstract: Autophagy, from the Greek words meaning “self‑eating”, is an evolutionarily conserved multistep process preserved amongst all eukaryotes to maintain cellular homeostasis(1). It is an intracellular, catabolic process whereby dysfunctional organelles such as mitochondria and inflammasomes, aggregated or unneeded proteins as well as intracellular bacteria and viruses and their components are degraded(2,3). The entities marked for destruction become surrounded by a double membrane structure called an autophagosome. The autophagosome fuses with a lysosome and the sequestered components are catabolized by lysosomal enzymes(4‑6). The resulting amino acids, fatty acids, carbohydrates and nucleic acid components are returned to the cytoplasm to provide additional nutrients for various metabolic processes. [...]

Source: LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

Authors: Athanasiou, Aikaterini, Leizer, Julie, Minis, Evelyn, Linhares, Lara M., Witkin, Steven S.

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7119434716

FWCI:

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Related to: 10