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Secondary Prophylaxis With Bioequivalent Generic Letermovir in Haploidentical Hematopoietic Stem Cell Transplantation: A Case Report

Year: 2026

Type: article

Abstract: Cytomegalovirus (CMV) reactivation poses a significant risk post-allogeneic hematopoietic stem cell transplantation (HSCT), particularly in high-risk settings. This report details the clinical course of a relapsed acute myeloid leukemia patient who underwent haploidentical HSCT following graft failure linked to CMV viremia. Letermovir prophylaxis effectively suppressed CMV but was discontinued on day +60, following which the patient experienced transient reactivation. The episode was successfully managed in the outpatient setting with oral valganciclovir. This case highlights the importance of sustained CMV prophylaxis and the role of accessible antiviral strategies in optimizing transplant outcomes.

Source: Cureus

DOI: 10.7759/cureus.101126

Authors: Abhijit Baheti, Suyash Bharat

Institutions: Deenanath Mangeshkar Hospital and Research Center, Zydus Lifesciences Limited (India)

Language: English

Topic: Cytomegalovirus and herpesvirus research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7119465436