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Figure S9 from RAS(ON) Multiselective Inhibition Drives Antitumor Immunity in Preclinical Models of NRAS-Mutant Melanoma

Year: 2026

Type: other

Abstract: Supplemental Figure 9: The RMC-7977 + anti-PD1 combination reprograms the tumor microenvironment to a more pro-inflammatory state. Violin plot showing the distribution of antigen presenting cells score across different myeloid cell populations identified by single-cell RNA sequencing. Each violin represents a distinct cell type, as indicated on the x-axis, and the width of each shape represents the density of cells at a given expression level of APC1. The y-axis represents normalized expression values. Colors correspond to cell identities as shown in the legend on the right side.

DOI: 10.1158/2326-6066.31028306

Authors: Larissa Anastacio Da Costa Carvalho, Nataliya Tovbis Shifrin, Manali S. Phadke, Michael F. Emmons, Ximo Pechuan-Jorge, Felix Mbuga, Oscar E. Ospina, Christopher Chow, Lillian Seu, Olivia L. Rose, Aparna Hegde, Nikhil I. Khushalani, Elsa Quintana, Keiran S.M. Smalley

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W7119469889

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