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Multicentric Reticulohistiocytosis: A Report of Two Cases

Year: 2026

Type: article

Abstract: Multicentric reticulohistiocytosis (MRH) is a rare histiocytic disorder with cutaneous and joint manifestations that most commonly affect middle-aged women. It is often misidentified as more common arthropathies and skin conditions, such as rheumatoid arthritis, dermatofibromas, progressive nodular histiocytomas, gouty tophi, and sarcoidosis, leading to incorrect treatment approaches. Here, we report two cases of MRH, diagnosed based on clinical and histopathological findings, who showed a significant response with the treatment of weekly methotrexate and tapering oral steroids.

Source: Clinical Dermatology Review

DOI: 10.4103/cdr.cdr_30_25

Authors: Soudamini Rajesh Tiwari, Pallavi Jagdish Yede, Pallavi Rupkumar Rokade, Bhagyashree Babanrao Supekar, Jayesh Ishwardas Mukhi

Institutions: Cooper Hospital, Government Medical College

Language: English

Topic: Histiocytic Disorders and Treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7119471853

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Cites: 11

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