Antiglomerular basement membrane disease(Goodpasture syndrome) associated with ANCA-negative central nervous system vasculitis
Year: 2026
Type: article
Study design: Case Report
Abstract: Anti-glomerular basement membrane disease is a rare pediatric autoimmune disease characterized by anti-glomerular basement membrane antibodies that cause rapidly progressive glomerulonephritis and alveolar hemorrhage. Central nervous system (CNS) involvement is sporadic. We present the case of a 13-year-old female patient with cerebral hemorrhage, septic shock, and multiorgan involvement, in whom the diagnosis of anti-glomerular basement membrane disease and CNS vasculitis in the absence of antineutrophil cytoplasmic antibodies (ANCA-negative) was confirmed. Combined treatment with glucocorticoids, cyclophosphamide, and plasmapheresis was performed, resulting in complete neurological and renal recovery. The rare coexistence of these two entities is analyzed. The case highlights the importance of maintaining a high index of diagnostic suspicion in the face of atypical clinical presentations.
Source: Archivos Argentinos de Pediatria
Institution: Hospital General de Niños Ricardo Gutierrez
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7119472075
FWCI:
Cites:
Cited by:
Related to: