Highly Speculative Single cell RNA seq show the microreziduu in FISS is not homogenuus
Year: 2026
Type: article
Abstract: I propose that FISS microresidual populations post-surgery are not phenotypically homogeneous but exist as threedistinct, dynamically interconvertingcellularstates: (1)Proliferative (mitoticallyactive, integrin-dependent), (2) Invasive (matrixdegrading,EMT-associated),and(3)Quiescent(metabolicallydormant,therapy-resistant).Furthermore,Ihypothesizethattherelativeproportionsofthesestatesshifttemporallypostoperatively, drivenbyevolvingwoundbedmicroenvironmental gradients (growth factors,ECMmaturation,metabolicstress).
Author: Stefan, Ionut Alexandru
Language: English
Topic: Cancer Cells and Metastasis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7119474270
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