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Cover Feature: Structural Characterization and AI‐Enhanced Modeling of a Broadly Neutralizing Camelid Antibody Against SARS‐CoV‐2 Variants (Adv. Therap. 1/2026)

Year: 2026

Type: article

Abstract: The cover image of the Research Article (DOI: 10.1002/adtp.202500244) by Katja Hanack, Ramasamy Paulmurugan, and co-workers shows the outcome of a multi-institutional collaborative effort developing a novel camelid antibody (B10) targeting SARS-CoV2 with wide spectrum neutralizing effect. This study systematically characterized the functional neutralizing effect of this antibody using epitope mapping, peptide fragment inhibition, neutralization, in silico molecular docking, and AI-directed structural design, to reveal the interaction of B10 with the Spike trimer from different variants. This newly generated antibody could be a potential candidate to efficiently neutralize a wide range of current and future variants of SARS-CoV-2 for broad clinical applications.

Source: Advanced Therapeutics

DOI: 10.1002/adtp.70113

Authors: Katja Hanack, Urszula Orzeł, Anja Schlör, Sourabh Mehta, Anandi Krishnan, Slawomir Filipek, Rushika Patel, Madhvi Joshi, Markus Hoffmann, Stefan Pöhlmann, Chaitanya Joshi, Dorian Liepmann, Ramasamy Paulmurugan, Venkatesan Renugopalakrishnan

Language: English

Topic: SARS-CoV-2 and COVID-19 Research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W7119476647

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