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Figure S6 from RAS(ON) Multiselective Inhibition Drives Antitumor Immunity in Preclinical Models of NRAS-Mutant Melanoma

Year: 2026

Type: other

Abstract: Supplemental Figure 6: The RMC-7977 + anti-PD1 combination reprograms the tumor microenvironment to a more pro-inflammatory state. (A) Dot plot showing the distribution of sample clusters (control, Anti-PD1, RMC-7977 and RMC-7977 + Anti-PD1) and annotations of major cell types identified. (B) Dot plot showing the expression of canonical marker genes of all group clusters.

DOI: 10.1158/2326-6066.31028318

Authors: Larissa Anastacio Da Costa Carvalho, Nataliya Tovbis Shifrin, Manali S. Phadke, Michael F. Emmons, Ximo Pechuan-Jorge, Felix Mbuga, Oscar E. Ospina, Christopher Chow, Lillian Seu, Olivia L. Rose, Aparna Hegde, Nikhil I. Khushalani, Elsa Quintana, Keiran S.M. Smalley

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W7119483217

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