Work

Teratoma as an Active Metabolic Reservoir

Year: 2026

Type: article

Abstract: Mature teratoma arising in non-seminomatous germ cell tumors (NSGCT) is conventionally regarded as chemoresistant but biologically inert residual tissue requiring surgicalexcision. This perspective is based primarily on histological observations of differentiated,non-proliferating cells with minimal mitotic activity. However, systems-level analysis of tumor ecosystem dynamics reveals a strikingly different picture: mature teratoma functionsas an active metabolic reservoir, structural scaffold, and microenvironmental stabilizer thatenables the survival and recurrence of aggressive embryonal components

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.18155585

Author: Stefan, Ionut Alexandru

Language: English

Topic: Testicular diseases and treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7119486389

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