Work

11 01 Base Architecture Hepatocellular Carcinoma NASH

Year: 2026

Type: article

Abstract: NASH-related HCC represents a unique metabolic malignancy characterized by profound organellar dysfunction, lipotoxic stress, and oxidative imbalance. Unlike viral-associated HCC,the NASH-HCC ecosystem is fundamentally driven by lipid overload and mitochondrial fragmentation, creating distinct vulnerabilities tha could potentially be exploitable through precision metabolic targeting.This framework models tumor progression through quantitative , spatial metabolic heterogeneity, and temporal feedback dynamics—all derived from fundamentalbiophysical and biochemical principles rather than empirical data fitting.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.18165742

Author: Stefan, Ionut Alexandru

Language: English

Topic: Cancer, Lipids, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7119494597

FWCI:

Cites:

Cited by:

Related to: