Work

CCDC97 is a Promising Predictor in Cancer Diagnosis: A Pan Cancer Analysis

Year: 2026

Type: article

Abstract: BACKGROUND: Coiled-coil domain-containing 97 (CCDC97) can bind to the splicing factor SF3B complex to participate significantly in pre-mRNA splicing. However, there may be a risk of cancer development in the case of disrupted mechanism, necessitating further in-depth investigation of the underlying mechanism. METHODS: The present study was conducted by searching for various databases to implement a comprehensive cancer analysis of CCDC97. Furthermore, a competitive endogenous RNA (ceRNA) network of CCDC97 was established, which was further integrated with the reported oncogene mechanisms in the CCDC family to explain the potential reasons for its abnormal expression. RESULTS: CCDC97 is highly expressed in various cancers and closely associated with poor prognosis. CCDC97 was also strongly associated with the infiltration of various immune cells and multiple immune checkpoints in the tumor immune microenvironment. RT-qPCR showed that CCDC97 was highly expressed in hepatocellular carcinoma (HCC) tissue samples. At the single-cell level, CCDC97 exhibited an intimate association with depleted T cells in HCC tissues. CONCLUSION: In cancers, particularly in HCC CCDC97 can serve as a promising marker for immunotherapy and prognosis in cancers, particularly in HCC. More experimental verification is needed in the future research.

Source: Analytical Cellular Pathology

DOI: 10.1155/ancp/2230769

Authors: Changye Yang, Ruirui Yang, Rundong Wang, Guo Ma, Lixin Hua

Institutions: Nantong University, Nantong University Xinglin College, Shandong First Medical University, Fudan University

Language: English

Topic: Cancer-related molecular mechanisms research

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,160