Work

Figure S3 from RAS(ON) Multiselective Inhibition Drives Antitumor Immunity in Preclinical Models of NRAS-Mutant Melanoma

Year: 2026

Type: other

Abstract: Supplemental Figure 3: RMC-7977 treatment leads to increased T cell infiltration. (A) Immunohistochemistry stained in red for CD8 of control (C, vehicle), responder (R, 3 days of treatment) and treatment escape (TE, 30 days of treatment). Scale bar = 200 µm. (B) Flow cytometry analysis of T cells (number of infiltrated CD4+ and CD8+ T cells, activated CD4+CD69+ and CD8+CD69+ T cells, and memory CD44+CD62L-CD4+ and CD44+CD62L-CD8+ T cells) of control, responder and treatment escape. (C) Multiplex IF scoring of whole slides stained for CD8, CD4, CD86, CD11b, CD11c, and Ly6G.

DOI: 10.1158/2326-6066.31028327

Authors: Larissa Anastacio Da Costa Carvalho, Nataliya Tovbis Shifrin, Manali S. Phadke, Michael F. Emmons, Ximo Pechuan-Jorge, Felix Mbuga, Oscar E. Ospina, Christopher Chow, Lillian Seu, Olivia L. Rose, Aparna Hegde, Nikhil I. Khushalani, Elsa Quintana, Keiran S.M. Smalley

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W7119496136

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