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19 02 Metastasis Base Architecture Ovarian Carcinoma HGSC BRCA-wild-type

Year: 2026

Type: article

Abstract: High-Grade Serous Ovarian Carcinoma (HGSC) exhibits a unique metastatic pattern fundamentally differentfrom other solid tumors: rather than hematogenous dissemination to distant organs, HGSC primarily spreadsthrough transcoelomic seeding within the peritoneal cavity, with secondary colonization of lung, liver, andlymph nodes. The ER-like subset of HGSC displays distinct metabolic characteristics, including lipid/glutaminedependence and estrogen receptor expression, creating specialized adaptation requirements for each metastaticniche.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.18167926

Author: Stefan, Ionut Alexandru

Language: English

Topic: Ovarian cancer diagnosis and treatment

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7119500650

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