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Figure S1 from RAS(ON) Multiselective Inhibition Drives Antitumor Immunity in Preclinical Models of NRAS-Mutant Melanoma

Year: 2026
Type: other
Abstract: Supplemental Figure 1: RMC-7977 leads to alterations in phospho-RTK and cytokine signaling. (A) Western Blot of phospho-ERK and AKT in SW1 cells treated with 8nM of RMC-7977 for 1-72h and semi-quantification graphs, n=2. (B) Western Blot of phospho-ERK and AKT in IPC298 cells treated with 3nM of RMC-7977 for 1-72h and semi-quantification graphs, n=2. One-way ANOVA was performed followed by Tukey’s multiple comparisons test: *p<0.05; **p<0.01; ***p<0.001; ****p<0.0001. (C) Phospho-RTK array assay and semi-quantification graph of SW1 cells treated with 8 nM of RMC-7977for 8 and 48h, n=2 (D) Phospho-RTK array assay and semi-quantification graph of IPC298 cells treated with 3nM of RMC-7977 for 8 and 48h, n=2. (E) Cytokine array of SW1 treated with 8nM for 48h. White bars represent downregulated cytokines and black bars upregulated cytokines, n=2
DOI: 10.1158/2326-6066.31028345
Authors: Larissa Anastacio Da Costa Carvalho, Nataliya Tovbis Shifrin, Manali S. Phadke, Michael F. Emmons, Ximo Pechuan-Jorge, Felix Mbuga, Oscar E. Ospina, Christopher Chow, Lillian Seu, Olivia L. Rose, Aparna Hegde, Nikhil I. Khushalani, Elsa Quintana, Keiran S.M. Smalley
Open Access status: gold
OpenAlex ID: W7119507399
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