Year: 2026
Type: article
Abstract: Circadian clocks coordinate physiology with daily cycles. Loss of circadian components disrupts bodily functions, but the phenotypes differ when disruption occurs during development or adulthood. Here, we compare effects of manipulating mammalian clock proteins across life stages, reviewing roles of BMAL1 and REV-ERBα/β in embryogenesis-skeletal formation, metabolic programming, cardiovascular development-and adulthood-tissue integrity, metabolic adaptation, neuroprotection. We further discuss mechanisms for dual involvement, and implications for stage-specific therapies.
Source: npj Biological Timing and Sleep
Institution: University of Pennsylvania
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,590
Funders: University of Pennsylvania, National Institutes of Health, Perelman School of Medicine, University of Pennsylvania, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases, Diabetes Research Center, Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania
OpenAlex ID: W7119507817