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03 02 Metastasis Base Architecture Lung Inflamatory Squamous Cell Carcinoma

Year: 2026

Type: article

Abstract: Key findings include: (1) Site-specific metabolic signatures– lymph nodes exhibit glycolytic dominance with MCT4-mediated lactate export (2.73 mM/h); lung metastases show oxidative metabolism withROS elevation (3.2× primary) and pentose phosphate pathway upregulation (4.5×); liver displays extremelipid droplet accumulation (12.2× TAG storage) with NRF2 constitutive activation; bone demonstrates bimodal dormancy (β-oxidation 70% ATP) versus reactivation (glycolytic switch); brain maintains ultra-highoxidative phosphorylation (75% ATP) with glutamate-mediated neurotoxicity.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.18158361

Author: Stefan, Ionut Alexandru

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7119516838

FWCI:

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