Work

Acute G6PD deficiency haemolytic crises with associated methaemoglobinaemia in a patient with typhoid

Year: 2026

Type: article

Abstract: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked disorder that increases red blood cell susceptibility to oxidative damage. While haemolysis is common, methaemoglobinaemia is a rare complication. A 39-year-old man developed both conditions, triggered by Salmonella typhi infection. Diagnosis was supported by Heinz bodies and blister cells on blood smear. Methylene blue and high-dose ascorbic acid were relatively contraindicated because of ongoing haemolysis and renal dysfunction. Contribution: This case highlights the importance of considering methaemoglobinaemia in G6PD deficiency during infections and adapting treatment when standard therapies are unsuitable.

Source: Southern African Journal of Infectious Diseases

DOI: 10.4102/sajid.v41i1.771

Authors: Jake P. Jacob, Midhun T. John, Lior Chernick

Institution: Helen Joseph Hospital

Language: English

Topic: Methemoglobinemia and Tumor Lysis Syndrome

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $597