Painful subcutaneous edema is associated with early age at disease onset in Immunoglobulin A vasculitis patients: A multicenter study
Year: 2026
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To evaluate the risk factors associated with the presence of Painful Subcutaneous Edema (PSE) in children and adolescents with Immunoglobulin A Vasculitis (IgAV). METHODS: A multicenter study evaluated 686 patients (≤ 18 years-old) at first 3-months after diagnosis. IgAV patients with PSE were compared to those without PSE. RESULTS: ) (43.8 % vs. 35.1 %, p = 0.04). Although associated with higher inflammatory markers, PSE was not linked to more severe outcomes. Logistic regression demonstrated that age at diagnosis was inversely associated with PSE (OR = 0.986; 95 % CI 0.981‒0.992; p < 0.001). CONCLUSION: PSE occurred in approximately one-third-of IgAV patients at disease onset and was diagnosed predominantly at an early age, with a more inflammatory presentation at onset. However, in spite of the higher levels of inflammatory markers, PSE was not linked to more severe outcomes.
Source: Clinics
Authors: Lia V. Steuer, Clara R. Doria, Matheus S. França, Paula S. Marra, Sebastian D. Cordoba, Luisa F.C. Forero, Ricardo N. Machado, Sylvia C.L. Farhat, Gleice Clemente, Vitória Curi, Claudio A. Len, Luciana M. Carvalho, Francisco H.R. Gomes, Virginia P.L. Ferriani, Rozana G. de Almeida, Flavio R. Sztajnbok, Lucia M.A. Campos, Adriana M. Elias, Verena A. Balbi, Nadia E. Aikawa, Beatriz O.L. Carneiro, Magda Carneiro-Sampaio, Katia T. Kozu, Clovis A.A. Silva
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,700
Awards: G2536006260, G4858035394, G6075573007
OpenAlex ID: W7119527617