09 01 Base Architecture Lung Small Cell Lung Carcinoma SCLC
Year: 2026
Type: article
Abstract: Small cell lung cancer originates from pulmonary neuroendocrine (Kulchitsky) cells with neuralcrest origin and constitutes 13-15% of all lung cancers [1]. Despite exquisite initial chemosensitivity (60-70% response rates to platinum-etoposide), SCLC exhibits near-universal recurrencewithin 4-6 months, with median overall survival of 9-11 months and 2-year survival <10% [3, 2].This paradox—initial vulnerability followed by inexorable resistance—motivates a systems-levelanalysis of tumor homeostasis, intrinsic heterogeneity, and adaptive compensation mechanisms
Author: Stefan, Ionut Alexandru
Language: English
Topic: Lung Cancer Research Studies
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7119530908
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